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- In early 2016, the definitions of sepsis and septic shock were updated, and the term severe sepsis was abandoned. Further investigation is needed to determine if such updates are appropriate for veterinary patients.
- The innate immune system is predominantly responsible for the initial manifestations of sepsis.
- Neutrophil extracellular traps (NETS) kill pathogens and may promote a prothrombotic state.
- The endothelial glycocalyx is the key determinant of vascular permeability.
- Continued research is needed to identify highly sensitive and specific biomarkers in patients with sepsis and septic shock.
Christopher G. Byers, DVM, DACVECC, DACVIM (SAIM), CVJ Board-Certified in Small Animal Emergency & Critical Care Board-Certified in Small Animal Internal Medicine Certified Veterinary Journalist
Dr. Byers is the Medical Director at VCA MidWest Veterinary Referral & Emergency Center in Omaha, Nebraska. He received his BS degree in Animal Sciences from Colorado State University, and his DVM from Cornell University’s College of Veterinary Medicine. He is board-certified in small animal emergency and critical care, as well as small animal internal medicine. He is also a Certified Veterinary Journalist in the American Society of Veterinary Journalists. Dr. Byers enjoys clinical research, and his current areas of interest include immune-mediated diseases and abdominal compartment syndrome. He publishes a weekly blog for pet owners: CriticalCareDVM.com with the sole purpose of educating pet parents about the benefits of partnering with board-certified veterinary specialists. He has co-authored the textbook, Handbook of Veterinary Emergency Protocols: Dog and Cat.